Skeletal Muscle TRIB3 Mediates Glucose Toxicity in Diabetes and High- Fat Diet–Induced Insulin Resistance

In the current study, we used muscle-specific TRIB3 overexpressing (MOE) and knockout (MKO) mice to determine whether TRIB3 mediates glucose-induced insulin resistance in diabetes and whether alterations in TRIB3 expression as a function of nutrient availability have a regulatory role in metabolism....

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Diabetes
Prif Awduron: Zhang, Wei, Wu, Mengrui, Kim, Teayoun, Jariwala, Ravi H., Garvey, W. John, Luo, Nanlan, Kang, Minsung, Ma, Elizabeth, Tian, Ling, Steverson, Dennis, Yang, Qinglin, Fu, Yuchang, Garvey, W. Timothy
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Diabetes Association 2016
Pynciau:
Pathophysiology
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955990/
https://ncbi.nlm.nih.gov/pubmed/27207527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0154
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