Novel Drug Design for Chagas Disease via Targeting Trypanosoma cruzi Tubulin: Homology Modeling and Binding Pocket Prediction on Trypanosoma cruzi Tubulin Polymerization Inhibition by Naphthoquinone Derivatives

Chagas disease, also called American trypanosomiasis, is a parasitic disease caused by Trypanosoma cruzi (T. cruzi). Recent findings have underscored the abundance of the causative organism, (T. cruzi), especially in the southern tier states of the US and the risk burden for the rural farming commun...

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Publicado en:Bioorg Med Chem
Main Authors: Ogindo, Charles O., Khraiwesh, Mozna H., George, Matthew, Brandy, Yakini, Brandy, Nailah, Gugssa, Ayele, Ashraf, Mohammad, Abbas, Muneer, Southerland, William M., Lee, Clarence M., Bakare, Oladapo, Fang, Yayin
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955813/
https://ncbi.nlm.nih.gov/pubmed/27345756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2016.06.031
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