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Loss of protein association causes cardiolipin degradation in Barth syndrome

Cardiolipin is a specific mitochondrial phospholipid that has a high affinity for proteins and that stabilizes the assembly of supercomplexes involved in oxidative phosphorylation. We found that sequestration of cardiolipin in protein complexes is critical to protect it from degradation. The turnove...

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Detalhes bibliográficos
Publicado no:Nat Chem Biol
Main Authors: Xu, Yang, Phoon, Colin K.L., Berno, Bob, D’Souza, Kenneth, Hoedt, Esthelle, Zhang, Guoan, Neubert, Thomas A., Epand, Richard M., Ren, Mindong, Schlame, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4955704/
https://ncbi.nlm.nih.gov/pubmed/27348092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nchembio.2113
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