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Multibody cofactor and substrate molecular recognition in the myo-inositol monophosphatase enzyme
Molecular recognition is rarely a two-body protein-ligand problem, as it often involves the dynamic interplay of multiple molecules that together control the binding process. Myo-inositol monophosphatase (IMPase), a drug target for bipolar disorder, depends on 3 Mg(2+) ions as cofactor for its catal...
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| 發表在: | Sci Rep |
|---|---|
| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4954947/ https://ncbi.nlm.nih.gov/pubmed/27440438 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep30275 |
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