20C, a bibenzyl compound isolated from Gastrodia elata, protects PC12 cells against rotenone-induced apoptosis via activation of the Nrf2/ARE/HO-1 signaling pathway

AIM: Our preliminary study shows that a bibenzyl compound isolated from Gastrodia elata, 2-[4-hydroxy-3-(4-hydroxybenzyl)benzyl]-4-(4-hydroxybenzyl)phenol (designated 20C), protects PC12 cells against H(2)O(2)-induced injury. In this study we investigated whether 20C exerted neuroprotective action i...

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Detalhes bibliográficos
Publicado no:Acta Pharmacol Sin
Main Authors: Huang, Ju-yang, Yuan, Yu-he, Yan, Jia-qing, Wang, Ya-nan, Chu, Shi-feng, Zhu, Cheng-gen, Guo, Qing-lan, Shi, Jian-gong, Chen, Nai-hong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954759/
https://ncbi.nlm.nih.gov/pubmed/27180985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/aps.2015.154
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