RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection

Retinoic acid inducible gene-I (RIG-I) is an innate RNA sensor that recognizes the influenza A virus (IAV) RNA genome and activates antiviral host responses. Here, we demonstrate that RIG-I signaling plays a crucial role in restricting IAV tropism and regulating host immune responses. Mice deficient...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Kandasamy, Matheswaran, Suryawanshi, Amol, Tundup, Smanla, Perez, Jasmine T., Schmolke, Mirco, Manicassamy, Santhakumar, Manicassamy, Balaji
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4954706/
https://ncbi.nlm.nih.gov/pubmed/27438481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1005754
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