A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells.

CD40 is a B-cell surface molecule that has been shown to induce B-cell growth upon ligation with monoclonal antibodies. This report shows that triggering via CD40 is essential for the activation of resting B cells by helper T cells (Th). A soluble fusion protein of CD40 and human immunoglobulin, CD4...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Noelle, R J, Roy, M, Shepherd, D M, Stamenkovic, I, Ledbetter, J A, Aruffo, A
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49539/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1378631/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.14.6550
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