PDZ-binding kinase/T-LAK cell-originated protein kinase is a target of the fucoidan from brown alga Fucus evanescens in the prevention of EGF-induced neoplastic cell transformation and colon cancer growth

The fucoidan with high anticancer activity was isolated from brown alga Fucus evanescens. The compound effectively prevented EGF-induced neoplastic cell transformation through inhibition of TOPK/ERK1/2/MSK 1 signaling axis. In vitro studies showed that the fucoidan attenuated mitogen-activated prote...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Vishchuk, Olesia S., Sun, Huimin, Wang, Zhe, Ermakova, Svetlana P., Xiao, JuanJuan, Lu, Tao, Xue, PeiPei, Zvyagintseva, Tatyana N., Xiong, Hua, Shao, Chen, Yan, Wei, Duan, Qiuhong, Zhu, Feng
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2016
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4951327/
https://ncbi.nlm.nih.gov/pubmed/26936995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.7708
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