Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein.

Germ-line mutations in the p53 tumor suppressor gene have been observed in patients with Li-Fraumeni syndrome, brain tumors, second malignancies, and breast cancers. It is unclear whether all of these mutations have inactivated p53 and thereby provide an increased risk for cancer. Therefore, it is n...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Frebourg, T, Kassel, J, Lam, K T, Gryka, M A, Barbier, N, Andersen, T I, Børresen, A L, Friend, S H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49511/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1631137/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.14.6413
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