White matter hyperintensities are more highly associated with preclinical Alzheimer's disease than imaging and cognitive markers of neurodegeneration

INTRODUCTION: Cognitive tests and nonamyloid imaging biomarkers do not consistently identify preclinical AD. The objective of this study was to evaluate whether white matter hyperintensity (WMH) volume, a cerebrovascular disease marker, is more associated with preclinical AD than conventional AD bio...

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Bibliographic Details
Published in:Alzheimers Dement (Amst)
Main Authors: Kandel, Benjamin M., Avants, Brian B., Gee, James C., McMillan, Corey T., Erus, Guray, Doshi, Jimit, Davatzikos, Christos, Wolk, David A.
Format: Artigo
Language:Inglês
Published: Elsevier 2016
Subjects:
Neuroimaging
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4950175/
https://ncbi.nlm.nih.gov/pubmed/27489875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.dadm.2016.03.001
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