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Biological pacemaker created by minimally invasive somatic reprogramming in pigs with complete heart block
Somatic reprogramming by reexpression of the embryonic transcription factor T-box 18 (TBX18) converts cardiomyocytes into pacemaker cells. We hypothesized that this could be a viable therapeutic avenue for pacemaker-dependent patients afflicted with device-related complications, and therefore tested...
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| Pubblicato in: | Sci Transl Med |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2014
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4949602/ https://ncbi.nlm.nih.gov/pubmed/25031269 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3008681 |
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