Sprouty2 and ‐4 hypomorphism promotes neuronal survival and astrocytosis in a mouse model of kainic acid induced neuronal damage

Sprouty (Spry) proteins play a key role as negative feedback inhibitors of the Ras/Raf/MAPK/ERK pathway downstream of various receptor tyrosine kinases. Among the four Sprouty isoforms, Spry2 and Spry4 are expressed in the hippocampus. In this study, possible effects of Spry2 and Spry4 hypomorphism...

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Detalles Bibliográficos
Publicado en:Hippocampus
Autores principales: Thongrong, Sitthisak, Hausott, Barbara, Marvaldi, Letizia, Agostinho, Alexandra S., Zangrandi, Luca, Burtscher, Johannes, Fogli, Barbara, Schwarzer, Christoph, Klimaschewski, Lars
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2015
Materias:
Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949526/
https://ncbi.nlm.nih.gov/pubmed/26540287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hipo.22549
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