1918 Influenza Receptor Binding Domain Variants Bind and Replicate in Primary Human Airway Cells Regardless of Receptor Specificity

The 1918 influenza pandemic caused ~50 million deaths. Many questions remain regarding the origin, pathogenicity, and mechanisms of human adaptation of this virus. Avian-adapted influenza A viruses preferentially bind α2,3-linked sialic acids (Sia) while human-adapted viruses preferentially bind α2,...

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Publicado no:Virology
Main Authors: Davis, A. Sally, Chertow, Daniel S., Kindrachuk, Jason, Qi, Li, Schwartzman, Louis M., Suzich, Jon, Alsaaty, Sara, Logun, Carolea, Shelhamer, James H., Taubenberger, Jeffery K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949484/
https://ncbi.nlm.nih.gov/pubmed/27062579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.virol.2016.03.025
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