Glucocorticoids Acutely Increase Brown Adipose Tissue Activity in Humans, Revealing Species-Specific Differences in UCP-1 Regulation

The discovery of brown adipose tissue (BAT) in adult humans presents a new therapeutic target for metabolic disease; however, little is known about the regulation of human BAT. Chronic glucocorticoid excess causes obesity in humans, and glucocorticoids suppress BAT activation in rodents. We tested w...

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Udgivet i:Cell Metab
Main Authors: Ramage, Lynne E., Akyol, Murat, Fletcher, Alison M., Forsythe, John, Nixon, Mark, Carter, Roderick N., van Beek, Edwin J.R., Morton, Nicholas M., Walker, Brian R., Stimson, Roland H.
Format: Artigo
Sprog:Inglês
Udgivet: Cell Press 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949380/
https://ncbi.nlm.nih.gov/pubmed/27411014
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2016.06.011
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