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Selective decreased de novo synthesis of glomerular proteoglycans under the influence of reactive oxygen species.

The effect of reactive oxygen species on de novo synthesis of heparan sulfate proteoglycans (HSPGs) of the renal glomerulus was investigated in an organ perfusion system. Isolated kidneys were perfused for 7 hr with a medium containing [35S]sulfate to label sulfated proteoglycans or [35S]methionine...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Kashihara, N, Watanabe, Y, Makino, H, Wallner, E I, Kanwar, Y S
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1992
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49490/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1631123/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.14.6309
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