Disruption of a binding site for hepatocyte nuclear factor 4 results in hemophilia B Leyden.

Hemophilia B Leyden is an X chromosome-linked bleeding disorder characterized by very low plasma levels of blood coagulation factor IX (fIX) during childhood. After puberty, plasma fIX levels gradually rise to a maximum of 60% of normal, probably under the influence of testosterone. Single point mut...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Reijnen, M J, Sladek, F M, Bertina, R M, Reitsma, P H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1992
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49488/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1631121/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.14.6300
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