Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism

Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme in triacylglycerol (TG) biosynthesis. Here we show that genetic deficiency and pharmacological inhibition of DGAT1 in mice alters cholesterol metabolism. Cholesterol absorption, as assessed by acute cholesterol uptake, was significant...

Descripció completa

Guardat en:
Dades bibliogràfiques
Publicat a:Biochim Biophys Acta
Autors principals: Sachdev, Vinay, Leopold, Christina, Bauer, Raimund, Patankar, Jay V., Iqbal, Jahangir, Obrowsky, Sascha, Boverhof, Renze, Doktorova, Marcela, Scheicher, Bernhard, Goeritzer, Madeleine, Kolb, Dagmar, Turnbull, Andrew V., Zimmer, Andreas, Hoefler, Gerald, Hussain, M. Mahmood, Groen, Albert K., Kratky, Dagmar
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948681/
https://ncbi.nlm.nih.gov/pubmed/27344248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2016.06.014
Etiquetes: Afegir etiqueta
Sense etiquetes, Sigues el primer a etiquetar aquest registre!

Ítems similars