Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism

Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme in triacylglycerol (TG) biosynthesis. Here we show that genetic deficiency and pharmacological inhibition of DGAT1 in mice alters cholesterol metabolism. Cholesterol absorption, as assessed by acute cholesterol uptake, was significant...

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Detalhes bibliográficos
Publicado no:Biochim Biophys Acta
Main Authors: Sachdev, Vinay, Leopold, Christina, Bauer, Raimund, Patankar, Jay V., Iqbal, Jahangir, Obrowsky, Sascha, Boverhof, Renze, Doktorova, Marcela, Scheicher, Bernhard, Goeritzer, Madeleine, Kolb, Dagmar, Turnbull, Andrew V., Zimmer, Andreas, Hoefler, Gerald, Hussain, M. Mahmood, Groen, Albert K., Kratky, Dagmar
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948681/
https://ncbi.nlm.nih.gov/pubmed/27344248
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2016.06.014
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