The hypoxia-inducible factor-1α activates ectopic production of fibroblast growth factor 23 in tumor-induced osteomalacia

Tumor-induced osteomalacia (TIO) is a rare paraneoplastic syndrome in which ectopic production of fibroblast growth factor 23 (FGF23) by non-malignant mesenchymal tumors causes phosphate wasting and bone fractures. Recent studies have implicated the hypoxia-inducible factor-1α (HIF-1α) in other phos...

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Bibliographic Details
Published in:Bone Res
Main Authors: Zhang, Qian, Doucet, Michele, Tomlinson, Ryan E, Han, Xiaobin, Quarles, L Darryl, Collins, Michael T, Clemens, Thomas L
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4948305/
https://ncbi.nlm.nih.gov/pubmed/27468359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/boneres.2016.11
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