Functional characterization of six aspartate (D) recombinant mojastin mutants (r-Moj): a second aspartate amino acid carboxyl to the RGD in r-Moj-D_ peptides is not sufficient to induce apoptosis of SK-Mel-28 cells

Disintegrins are small peptides produced in viper venom that act as integrin antagonists. When bound to integrins, disintegrins induce altered cellular behaviors, such as apoptotic induction. Disintegrins with RGDDL or RGDDM motifs induce apoptosis of normal and cancer cells. We hypothesized that a...

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Detalhes bibliográficos
Publicado no:Toxicon
Main Authors: Ramos, Carla J., Gutierrez, Daniel A., Aranda, Ana S., Koshlaychuk, Melissa A., Carrillo, David A., Medrano, Rafael, McBride, Terri D., U, Andrew, Medina, Stephanie M., Lombardo, Melissa C., Lucena, Sara E., Sanchez, Elda E., Soto, Julio G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947553/
https://ncbi.nlm.nih.gov/pubmed/27105671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxicon.2016.04.038
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