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Dynamic deformability of sickle red blood cells in microphysiological flow

In sickle cell disease (SCD), hemoglobin molecules polymerize intracellularly and lead to a cascade of events resulting in decreased deformability and increased adhesion of red blood cells (RBCs). Decreased deformability and increased adhesion of sickle RBCs lead to blood vessel occlusion (vaso-occl...

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Detalles Bibliográficos
Publicado en:Technology (Singap World Sci)
Main Authors: Alapan, Y., Matsuyama, Y., Little, J. A., Gurkan, U. A.
Formato: Artigo
Idioma:Inglês
Publicado: 2016
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947547/
https://ncbi.nlm.nih.gov/pubmed/27437432
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1142/S2339547816400045
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