Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model

BACKGROUND: Insulin-like growth factor 1 (IGF-1) and hepatocyte growth factor (HGF) are among the most promising growth factors for promoting cardiorepair. Here, we evaluated the combination of cell- and gene-based therapy using mesenchymal stem cells (MSC) genetically modified to overexpress IGF-1...

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Detalhes bibliográficos
Publicado no:Stem Cell Res Ther
Main Authors: Gómez-Mauricio, Guadalupe, Moscoso, Isabel, Martín-Cancho, María-Fernanda, Crisóstomo, Verónica, Prat-Vidal, Cristina, Báez-Díaz, Claudia, Sánchez-Margallo, Francisco M., Bernad, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947339/
https://ncbi.nlm.nih.gov/pubmed/27423905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13287-016-0350-z
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