Decreased NK-cell tumour immunosurveillance consequent to JAK inhibition enhances metastasis in breast cancer models

The JAK/STAT pathway is an attractive target for breast cancer therapy due to its frequent activation, and clinical trials evaluating JAK inhibitors (JAKi) in advanced breast cancer are ongoing. Using patient biopsies and preclinical models of breast cancer, we demonstrate that the JAK/STAT pathway...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Udgivet i:Nat Commun
Main Authors: Bottos, Alessia, Gotthardt, Dagmar, Gill, Jason W., Gattelli, Albana, Frei, Anna, Tzankov, Alexandar, Sexl, Veronika, Wodnar-Filipowicz, Aleksandra, Hynes, Nancy E.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4947169/
https://ncbi.nlm.nih.gov/pubmed/27406745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms12258
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker