MMP-8 Is Critical for Dexamethasone Therapy in Alkali-Burned Corneas Under Dry Eye Conditions

Our previous studies have shown that Dexamethasone (Dex) reduced the expression of matrix-metalloproteinases (MMPs -1,-3,-9,-13), IL-1β and IL-6, while it significantly increased MMP-8 mRNA transcripts in a concomitant dry eye and corneal alkali burn murine model (CM). To investigate if MMP-8 induct...

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Bibliografiske detaljer
Udgivet i:J Cell Physiol
Main Authors: BIAN, FANG, WANG, CHANGJUN, TUKLER-HENRIKSSON, JOHANNA, PFLUGFELDER, STEPHEN C., CAMODECA, CATERINA, NUTI, ELISA, ROSSELLO, ARMANDO, LI, DE-QUAN, DE PAIVA, CINTIA S.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946998/
https://ncbi.nlm.nih.gov/pubmed/26923552
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.25364
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