Urokinase-type Plasminogen Activator (uPA) Promotes Angiogenesis by Attenuating Proline-rich Homeodomain Protein (PRH) Transcription Factor Activity and De-repressing Vascular Endothelial Growth Factor (VEGF) Receptor Expression

Urokinase-type plasminogen activator (uPA) regulates angiogenesis and vascular permeability through proteolytic degradation of extracellular matrix and intracellular signaling initiated upon its binding to uPAR/CD87 and other cell surface receptors. Here, we describe an additional mechanism by which...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Stepanova, Victoria, Jayaraman, Padma-Sheela, Zaitsev, Sergei V., Lebedeva, Tatiana, Bdeir, Khalil, Kershaw, Rachael, Holman, Kelci R., Parfyonova, Yelena V., Semina, Ekaterina V., Beloglazova, Irina B., Tkachuk, Vsevolod A., Cines, Douglas B.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946921/
https://ncbi.nlm.nih.gov/pubmed/27151212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.678490
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