Sulfur Denitrosylation by an Engineered Trx-like DsbG Enzyme Identifies Nucleophilic Cysteine Hydrogen Bonds as Key Functional Determinant

Exposure of bacteria to NO results in the nitrosylation of cysteine thiols in proteins and low molecular weight thiols such as GSH. The cells possess enzymatic systems that catalyze the denitrosylation of these modified sulfurs. An important player in these systems is thioredoxin (Trx), a ubiquitous...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:J Biol Chem
Huvudupphovsmän: Lafaye, Céline, Van Molle, Inge, Tamu Dufe, Veronica, Wahni, Khadija, Boudier, Ariane, Leroy, Pierre, Collet, Jean-François, Messens, Joris
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2016
Ämnen:
Protein Structure and Folding
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946920/
https://ncbi.nlm.nih.gov/pubmed/27226614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.729426
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk