mTOR Inhibition: Reduced Insulin Secretion and Sensitivity in a Rat Model of Metabolic Syndrome

BACKGROUND: Sirolimus (SRL) has been associated with new-onset diabetes mellitus after transplantation. The aim was to determine the effect of SRL on development of insulin resistance and β-cell toxicity. METHODS: Lean Zucker rat (LZR) and obese Zucker rat (OZR) were distributed into groups: vehicle...

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Detalhes bibliográficos
Publicado no:Transplant Direct
Main Authors: Rovira, Jordi, Ramírez-Bajo, María Jose, Banon-Maneus, Elisenda, Moya-Rull, Daniel, Ventura-Aguiar, Pedro, Hierro-Garcia, Natalia, Lazo-Rodriguez, Marta, Revuelta, Ignacio, Torres, Armando, Oppenheimer, Federico, Campistol, Josep M., Diekmann, Fritz
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2016
Assuntos:
Original Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946492/
https://ncbi.nlm.nih.gov/pubmed/27500257
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TXD.0000000000000576
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