Kidneys From α1,3-Galactosyltransferase Knockout/Human Heme Oxygenase-1/Human A20 Transgenic Pigs Are Protected From Rejection During Ex Vivo Perfusion With Human Blood

Multiple modifications of the porcine genome are required to prevent rejection after pig-to-primate xenotransplantation. Here, we produced pigs with a knockout of the α1,3-galactosyltransferase gene (GGTA1-KO) combined with transgenic expression of the human anti-apoptotic/anti-inflammatory molecule...

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Detalhes bibliográficos
Publicado no:Transplant Direct
Main Authors: Ahrens, Hellen E., Petersen, Björn, Ramackers, Wolf, Petkov, Stoyan, Herrmann, Doris, Hauschild-Quintern, Janet, Lucas-Hahn, Andrea, Hassel, Petra, Ziegler, Maren, Baars, Wiebke, Bergmann, Sabine, Schwinzer, Reinhard, Winkler, Michael, Niemann, Heiner
Formato: Artigo
Idioma:Inglês
Publicado em: Lippincott Williams & Wilkins 2015
Assuntos:
Original Basic Science
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946468/
https://ncbi.nlm.nih.gov/pubmed/27500225
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TXD.0000000000000533
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