A Cross-Species Analysis in Pancreatic Neuroendocrine Tumors Reveals Molecular Subtypes with Distinctive Clinical, Metastatic, Developmental, and Metabolic Characteristics

Seeking to assess the representative and instructive value of an engineered mouse model of pancreatic neuroendocrine tumors (PanNET) for its cognate human cancer, we profiled and compared mRNA and miRNA transcriptomes of tumors from both. Mouse PanNET tumors could be classified into two distinctive...

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Detalhes bibliográficos
Publicado no:Cancer Discov
Main Authors: Sadanandam, Anguraj, Wullschleger, Stephan, Lyssiotis, Costas A., Grötzinger, Carsten, Barbi, Stefano, Bersani, Samantha, Körner, Jan, Wafy, Ismael, Mafficini, Andrea, Lawlor, Rita T., Simbolo, Michele, Asara, John M., Bläker, Hendrik, Cantley, Lewis C., Wiedenmann, Bertram, Scarpa, Aldo, Hanahan, Douglas
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4946251/
https://ncbi.nlm.nih.gov/pubmed/26446169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-15-0068
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