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N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines
The search for novel anticancer therapeutics with the ability to overcome multi-drug resistance (MDR) mechanisms is of high priority. A class of molecules that show potential in overcoming MDR are the N-alkylated isatins. In particular 5,7-dibromo-N-alkylisatins are potent microtubule destabilizing...
Gorde:
| Argitaratua izan da: | Heliyon |
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| Egile Nagusiak: | , , , , , , |
| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Elsevier
2016
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4945850/ https://ncbi.nlm.nih.gov/pubmed/27441242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2015.e00060 |
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