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N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines
The search for novel anticancer therapeutics with the ability to overcome multi-drug resistance (MDR) mechanisms is of high priority. A class of molecules that show potential in overcoming MDR are the N-alkylated isatins. In particular 5,7-dibromo-N-alkylisatins are potent microtubule destabilizing...
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| Publicat a: | Heliyon |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Elsevier
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4945850/ https://ncbi.nlm.nih.gov/pubmed/27441242 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2015.e00060 |
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