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N-alkylated isatins evade P-gp mediated efflux and retain potency in MDR cancer cell lines

The search for novel anticancer therapeutics with the ability to overcome multi-drug resistance (MDR) mechanisms is of high priority. A class of molecules that show potential in overcoming MDR are the N-alkylated isatins. In particular 5,7-dibromo-N-alkylisatins are potent microtubule destabilizing...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Heliyon
Egile Nagusiak: Vine, Kara L., Belfiore, Lisa, Jones, Luke, Locke, Julie M., Wade, Samantha, Minaei, Elahe, Ranson, Marie
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Elsevier 2016
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945850/
https://ncbi.nlm.nih.gov/pubmed/27441242
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.heliyon.2015.e00060
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