Neutrophil maturation rate determines the effects of dipeptidyl peptidase 1 inhibition on neutrophil serine protease activity

BACKGROUND AND PURPOSE: Neutrophil serine proteases (NSPs) are activated by dipeptidyl peptidase 1 (DPP1) during neutrophil maturation. The effects of neutrophil turnover rate on NSP activity following DPP1 inhibition was studied in a rat pharmacokinetic/pharmacodynamic model. EXPERIMENTAL APPROACH:...

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Pubblicato in:Br J Pharmacol
Autori principali: Gardiner, P, Wikell, C, Clifton, S, Shearer, J, Benjamin, A, Peters, S A
Natura: Artigo
Lingua:Inglês
Pubblicazione: John Wiley and Sons Inc. 2016
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945769/
https://ncbi.nlm.nih.gov/pubmed/27186823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13515
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