Effect of flecainide derivatives on sarcoplasmic reticulum calcium release suggests a lack of direct action on the cardiac ryanodine receptor

BACKGROUND AND PURPOSE: Flecainide is a use‐dependent blocker of cardiac Na(+) channels. Mechanistic analysis of this block showed that the cationic form of flecainide enters the cytosolic vestibule of the open Na(+) channel. Flecainide is also effective in the treatment of catecholaminergic polymor...

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Detalles Bibliográficos
Publicado en:Br J Pharmacol
Main Authors: Bannister, Mark L, Alvarez‐Laviada, Anita, Thomas, N Lowri, Mason, Sammy A, Coleman, Sharon, du Plessis, Christo L, Moran, Abbygail T, Neill‐Hall, David, Osman, Hasnah, Bagley, Mark C, MacLeod, Kenneth T, George, Christopher H, Williams, Alan J
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945764/
https://ncbi.nlm.nih.gov/pubmed/27237957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13521
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