A Single Nucleotide Polymorphism in the Il17ra Promoter Is Associated with Functional Severity of Ankylosing Spondylitis

The aim of this study was to identify new genetic variants associated with the severity of ankylosing spondylitis (AS). We sequenced the exome of eight patients diagnosed with AS, selected on the basis of the severity of their clinical parameters. We identified 27 variants in exons and regulatory re...

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Bibliografiska uppgifter
I publikationen:PLoS One
Huvudupphovsmän: Vidal-Castiñeira, Jose Ramón, López-Vázquez, Antonio, Diaz-Peña, Roberto, Diaz-Bulnes, Paula, Martinez-Camblor, Pablo, Coto, Eliecer, Coto-Segura, Pablo, Bruges-Armas, Jacome, Pinto, Jose Antonio, Blanco, Francisco Jose, Sánchez, Alejandra, Mulero, Juan, Queiro, Ruben, Lopez-Larrea, Carlos
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2016
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4945092/
https://ncbi.nlm.nih.gov/pubmed/27415816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0158905
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