Antagonizing integrin beta3 increases immune suppression in cancer

Integrin beta3 is critical for tumor invasion, neoangiogenesis, and inflammation making it a promising cancer target. However, preclinical and clinical data of integrin beta3 antagonists have demonstrated no benefit or worse outcomes. We hypothesized that integrin beta3 could affect tumor immunity a...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Su, Xinming, Esser, Alison K., Amend, Sarah R., Xiang, Jingyu, Xu, Yalin, Ross, Michael H, Fox, Gregory C., Kobayashi, Takayuki, Steri, Veronica, Roomp, Kirsten, Fontana, Francesca, Hurchla, Michelle A., Knolhoff, Brett L., Meyer, Melissa A., Morgan, Elizabeth A., Tomasson, Julia C., Novack, Joshua S., Zou, Wei, Faccio, Roberta, Novack, Deborah V., Robinson, Stephen D., Teitelbaum, Steven L., DeNardo, David G., Schneider, Jochen G., Weilbaecher, Katherine N.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944657/
https://ncbi.nlm.nih.gov/pubmed/27216180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-15-2663
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