ISG12a Restricts Hepatitis C Virus Infection through the Ubiquitination-Dependent Degradation Pathway

Interferons (IFNs) restrict various kinds of viral infection via induction of hundreds of IFN-stimulated genes (ISGs), while the functions of the majority of ISGs are broadly unclear. Here, we show that a high-IFN-inducible gene, ISG12a (also known as IFI27), exhibits a nonapoptotic antiviral effect...

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Pubblicato in:J Virol
Autori principali: Xue, Binbin, Yang, Darong, Wang, Jingjing, Xu, Yan, Wang, Xiaohong, Qin, Yuwen, Tian, Renyun, Chen, Shengwen, Xie, Qinya, Liu, Nianli, Zhu, Haizhen
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2016
Soggetti:
Cellular Response to Infection
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944290/
https://ncbi.nlm.nih.gov/pubmed/27194766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00352-16
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