Effects of MF59 Adjuvant on Induction of Isotype-Switched IgG Antibodies and Protection after Immunization with T-Dependent Influenza Virus Vaccine in the Absence of CD4(+) T Cells

CD4(+) T cells play a central role in orchestrating adaptive immunity. To better understand the roles of CD4(+) T cells in the effects of adjuvants, we investigated the efficacy of a T-dependent influenza virus split vaccine with MF59 or alum in CD4 knockout (CD4KO) and wild-type (WT) mice. CD4(+) T...

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Vydáno v:J Virol
Hlavní autoři: Ko, Eun-Ju, Lee, Young-Tae, Kim, Ki-Hye, Jung, Yu-Jin, Lee, Youri, Denning, Timothy L., Kang, Sang-Moo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2016
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944285/
https://ncbi.nlm.nih.gov/pubmed/27226368
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00339-16
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