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Identification of novel candidate drivers connecting different dysfunctional levels for lung adenocarcinoma using protein-protein interactions and a shortest path approach

Tumors are formed by the abnormal proliferation of somatic cells with disordered growth regulation under the influence of tumorigenic factors. Recently, the theory of “cancer drivers” connects tumor initiation with several specific mutations in the so-called cancer driver genes. According to the dif...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Chen, Lei, Huang, Tao, Zhang, Yu-Hang, Jiang, Yang, Zheng, Mingyue, Cai, Yu-Dong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944139/
https://ncbi.nlm.nih.gov/pubmed/27412431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep29849
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