Tumor Necrosis Factor Alpha Inhibits L-Type Ca(2+) Channels in Sensitized Guinea Pig Airway Smooth Muscle through ERK 1/2 Pathway

Tumor necrosis factor alpha (TNF-α) is a potent proinflammatory cytokine that plays a significant role in the pathogenesis of asthma by inducing hyperresponsiveness and airway remodeling. TNF-α diminishes the L-type voltage dependent Ca(2+) channel (L-VDCC) current in cardiac myocytes, an observatio...

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Detalhes bibliográficos
Publicado no:Mediators Inflamm
Main Authors: Reyes-García, Jorge, Flores-Soto, Edgar, Solís-Chagoyán, Héctor, Sommer, Bettina, Díaz-Hernández, Verónica, García-Hernández, Luz María, Montaño, Luis M.
Formato: Artigo
Idioma:Inglês
Publicado em: Hindawi Publishing Corporation 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4944077/
https://ncbi.nlm.nih.gov/pubmed/27445440
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2016/5972302
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