Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses.

Transgenic mice lacking an intact beta 2-microglobulin (beta 2m) gene fail to express major histocompatibility complex (MHC) class I proteins on the cell surface and, as a result, are virtually devoid of CD4- CD8+ lymphocytes. These animals provide a unique model system for directly assessing the ro...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Spriggs, M K, Koller, B H, Sato, T, Morrissey, P J, Fanslow, W C, Smithies, O, Voice, R F, Widmer, M B, Maliszewski, C R
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1992
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC49439/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1631092/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.89.13.6070
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