Nerve growth factor receptor negates the tumor suppressor p53 as a feedback regulator

Cancer develops and progresses often by inactivating p53. Here, we unveil nerve growth factor receptor (NGFR, p75NTR or CD271) as a novel p53 inactivator. p53 activates NGFR transcription, whereas NGFR inactivates p53 by promoting its MDM2-mediated ubiquitin-dependent proteolysis and by directly bin...

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Bibliographische Detailangaben
Veröffentlicht in:eLife
Hauptverfasser: Zhou, Xiang, Hao, Qian, Liao, Peng, Luo, Shiwen, Zhang, Minhong, Hu, Guohui, Liu, Hongbing, Zhang, Yiwei, Cao, Bo, Baddoo, Melody, Flemington, Erik K, Zeng, Shelya X, Lu, Hua
Format: Artigo
Sprache:Inglês
Veröffentlicht: eLife Sciences Publications, Ltd 2016
Schlagworte:
Cancer Biology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943851/
https://ncbi.nlm.nih.gov/pubmed/27282385
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15099
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