A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation

Subcellular compartmentation of the ubiquitous second messenger cAMP has been widely proposed as a mechanism to explain unique receptor-dependent functional responses. How exactly compartmentation is achieved, however, has remained a mystery for more than 40 years. In this study, we developed comput...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: Yang, Pei-Chi, Boras, Britton W., Jeng, Mao-Tsuen, Docken, Steffen S., Lewis, Timothy J., McCulloch, Andrew D., Harvey, Robert D., Clancy, Colleen E.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943723/
https://ncbi.nlm.nih.gov/pubmed/27409243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005005
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