Physiological, Behavioral, and Histological Responses of Male C57BL/6N Mice to Different CO(2) Chamber Replacement Rates

Rodent euthanasia with CO(2) by using gradual displacement of 10% to 30% of the chamber volume per minute is considered acceptable by the AVMA Panel on Euthanasia. However, whether a 50% to 100% chamber replacement rate (CRR) of CO(2) is more painful or distressful than 10% to 30% CRR is unclear. Th...

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Udgivet i:J Am Assoc Lab Anim Sci
Main Authors: Boivin, Gregory P, Bottomley, Michael A, Dudley, Emily S, Schiml, Patricia A, Wyatt, Christopher N, Grobe, Nadja
Format: Artigo
Sprog:Inglês
Udgivet: American Association for Laboratory Animal Science 2016
Fag:
Experimental Use
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943617/
https://ncbi.nlm.nih.gov/pubmed/27423153
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