Heme-bound SiaA from Streptococcus pyogenes: Effects of Mutations and Oxidation State on Protein Stability

The protein SiaA (HtsA) is part of a heme uptake pathway in Streptococcus pyogenes. In this report, we present the heme binding of the alanine mutants of the axial histidine (H229A) and methionine (M79A) ligands, as well as a lysine (K61A) and cysteine (C58A) located near the heme propionates (based...

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Detalhes bibliográficos
Publicado no:J Inorg Biochem
Main Authors: Akbas, Neval, Draganova, Elizabeth B., Block, Darci R., Sook, Brian R., Chan, Yau Fong, Zhuo, Joy, Eichenbaum, Zehava, Rodgers, Kenton R., Dixon, Dabney W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4943329/
https://ncbi.nlm.nih.gov/pubmed/26746808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jinorgbio.2015.10.016
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