Antiphospholipid antibody-induced miR-146a-3p drives trophoblast interleukin-8 secretion through activation of Toll-like receptor 8

STUDY QUESTION: What is the role of microRNAs (miRs) in antiphospholipid antibody (aPL)-induced trophoblast inflammation? SUMMARY ANSWER: aPL-induced up-regulation of trophoblast miR-146a-3p is mediated by Toll-like receptor 4 (TLR4), and miR-146a-3p in turn drives the cells to secrete interleukin (...

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Bibliografski detalji
Izdano u:Mol Hum Reprod
Glavni autori: Gysler, Stefan M., Mulla, Melissa J., Guerra, Marta, Brosens, Jan J., Salmon, Jane E., Chamley, Lawrence W., Abrahams, Vikki M.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2016
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941806/
https://ncbi.nlm.nih.gov/pubmed/27029214
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/molehr/gaw027
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