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On the ability of molecular dynamics force fields to recapitulate NMR derived protein side chain order parameters

Molecular dynamics (MD) simulations have become a central tool for investigating various biophysical questions with atomistic detail. While many different proxies are used to qualify MD force fields, most are based on largely structural parameters such as the root mean square deviation from experime...

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Detalhes bibliográficos
Publicado no:Protein Sci
Main Authors: O'Brien, Evan S., Wand, A. Joshua, Sharp, Kim A.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941777/
https://ncbi.nlm.nih.gov/pubmed/26990788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pro.2922
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