A metabolic intermediate of the fructose-asparagine utilization pathway inhibits growth of a Salmonella fraB mutant

Insertions in the Salmonella enterica fra locus, which encodes the fructose-asparagine (F-Asn) utilization pathway, are highly attenuated in mouse models of inflammation (>1000-fold competitive index). Here, we report that F-Asn is bacteriostatic to a fraB mutant (IC(50) 19 μM), but not to the wi...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Sabag-Daigle, Anice, Blunk, Henry M., Sengupta, Anindita, Wu, Jikang, Bogard, Alexander J., Ali, Mohamed M., Stahl, Christopher, Wysocki, Vicki H., Gopalan, Venkat, Behrman, Edward J., Ahmer, Brian M. M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941530/
https://ncbi.nlm.nih.gov/pubmed/27403719
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep28117
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