Linear mixed model for heritability estimation that explicitly addresses environmental variation

The linear mixed model (LMM) is now routinely used to estimate heritability. Unfortunately, as we demonstrate, LMM estimates of heritability can be inflated when using a standard model. To help reduce this inflation, we used a more general LMM with two random effects—one based on genomic variants an...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Heckerman, David, Gurdasani, Deepti, Kadie, Carl, Pomilla, Cristina, Carstensen, Tommy, Martin, Hilary, Ekoru, Kenneth, Nsubuga, Rebecca N., Ssenyomo, Gerald, Kamali, Anatoli, Kaleebu, Pontiano, Widmer, Christian, Sandhu, Manjinder S.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Sackler Colloquium on Drawing Causal Inference from Big Data
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4941438/
https://ncbi.nlm.nih.gov/pubmed/27382152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1510497113
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