Gender‐related differential effect of tachykinin NK(2) receptor‐mediated visceral hyperalgesia in guinea pig colon

BACKGROUND AND PURPOSE: The tachykinin NK(2) receptor antagonist ibodutant is under Phase III clinical investigation to treat female patients with irritable bowel syndrome. The aim of this study was to investigate the NK(2) receptor‐related gender specificity in a model of colitis. EXPERIMENTAL APPR...

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Detalhes bibliográficos
Publicado no:Br J Pharmacol
Main Authors: Bellucci, F, Buéno, L, Bugianesi, R, Crea, A, D'Aranno, V, Meini, S, Santicioli, P, Tramontana, M, Maggi, CA
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2016
Assuntos:
Research Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940818/
https://ncbi.nlm.nih.gov/pubmed/26758701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13427
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