Deletion of the type-1 interferon receptor in APP(SWE)/PS1(ΔE9) mice preserves cognitive function and alters glial phenotype

A neuro-inflammatory response is evident in Alzheimer’s disease (AD), yet the precise mechanisms by which neuro-inflammation influences the progression of Alzheimer’s disease (AD) remain poorly understood. Type-1 interferons (IFNs) are master regulators of innate immunity and have been implicated in...

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Detalhes bibliográficos
Publicado no:Acta Neuropathol Commun
Main Authors: Minter, Myles R., Moore, Zachery, Zhang, Moses, Brody, Kate M., Jones, Nigel C., Shultz, Sandy R., Taylor, Juliet M., Crack, Peter J.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4940712/
https://ncbi.nlm.nih.gov/pubmed/27400725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-016-0341-4
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