Interstitial Pressure in Pancreatic Ductal Adenocarcinoma Is Dominated by a Gel-Fluid Phase

Elevated interstitial fluid pressure can present a substantial barrier to drug delivery in solid tumors. This is particularly true of pancreatic ductal adenocarcinoma, a highly lethal disease characterized by a robust fibroinflammatory response, widespread vascular collapse, and hypoperfusion that t...

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Detalhes bibliográficos
Publicado no:Biophys J
Main Authors: DuFort, Christopher C., DelGiorno, Kathleen E., Carlson, Markus A., Osgood, Ryan J., Zhao, Chunmei, Huang, Zhongdong, Thompson, Curtis B., Connor, Robert J., Thanos, Christopher D., Scott Brockenbrough, J., Provenzano, Paolo P., Frost, Gregory I., Michael Shepard, H., Hingorani, Sunil R.
Formato: Artigo
Idioma:Inglês
Publicado em: The Biophysical Society 2016
Assuntos:
Systems Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939548/
https://ncbi.nlm.nih.gov/pubmed/27166818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.03.040
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