In depth evaluation of the prognostic and predictive utility of PTEN immunohistochemistry in colorectal carcinomas: performance of three antibodies with emphasis on intracellular and intratumoral heterogeneity

BACKGROUND: Phosphatase and tensin homolog deleted in chromosome 10 (PTEN) loss of function is frequently detected in advanced colorectal cancer. Its detection is thought to have prognostic significance and it is being considered to predict responsiveness to anti-EGFR therapy. Unfortunately, while i...

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Bibliografiske detaljer
Udgivet i:Diagn Pathol
Main Authors: Ágoston, Emese Irma, Micsik, Tamás, Ács, Balázs, Fekete, Krisztina, Hahn, Oszkár, Baranyai, Zsolt, Dede, Kristóf, Bodoky, György, Bursics, Attila, Kulka, Janina, Krenács, Tibor, Győrffy, Balázs, Harsányi, László, Szász, A. Marcell
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2016
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4939017/
https://ncbi.nlm.nih.gov/pubmed/27392434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13000-016-0508-0
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